Oblimersen sodium

Pronunciation

Definition 1

A substance being studied in the treatment of cancer. It may kill cancer cells by blocking the production of a protein that makes cancer cells live longer and by making them more sensitive to anticancer drugs. It is a type of antisense oligodeoxyribonucleotide. Also called augmerosen, bcl-2 antisense oligodeoxynucleotide G3139, and Genasense. (NCI Dictionary)

Definition 2

The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy. The anti-apoptotic bcl-2 protein is an integral outer mitochondrial membrane protein (OMMP) that is overexpressed in some cancer cell types and is linked to tumor drug resistance. (NCI Thesaurus)

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The geometry of an object that is shaped like a spheroid compressed at the poles.

Objective response

A measurable response.

Objective improvement

An improvement that can be measured by the health care provider (for example, when a tumor shrinks or there are fewer cancer…

Objective Evidence

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Objective

A goal or aim to be accomplished or attained.