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Observed Area Under the Curve Percent Back Extrapolation
Definition 1
The percentage of the area under the curve (AUC) extrapolated to infinity that was due to back extrapolation to estimate concentration at time zero, based upon observed values. (NCI Thesaurus)
Definition 2
Applies only for intravascular bolus dosing. The area under the curve (AUC) from the first measured concentration value back extrapolated to the concentration value at time zero as a percentage of the area under the curve extrapolated to infinity using the observed value of the last non-zero concentration. (NCI Thesaurus/CDISC)
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