Omacetaxine mepesuccinate

Pronunciation

Definition 1

A drug used to treat certain types of chronic myelogenous leukemia (CML) that have not gotten better after treatment with other anticancer drugs. It is also being studied in the treatment of other types of cancer. Omacetaxine mepesuccinate blocks certain proteins involved in cancer cell growth and may kill cancer cells. It is a type of plant alkaloid. Also called homoharringtonine and Synribo. (NCI Dictionary)

Definition 2

A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine mepesuccinate binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types. (NCI Thesaurus)

Definition 3

An anticancer drug that belongs to the plant alkaloid family of drugs. (NCI Dictionary)

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