Physical dependence

Pronunciation

Definition 1

A condition in which a person takes a drug over time, and unpleasant physical symptoms occur if the drug is suddenly stopped or taken in smaller doses. (NCI Dictionary)

Definition 2

The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the opioid is stopped or an opioid antagonist is administered. (NCI Thesaurus)

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