PIK3CA wt Allele

Human PIK3CA wild-type allele is located in the vicinity of 3q26.3 and is approximately 36 kb in length. This allele, which encodes phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform protein, plays a role in signaling pathways underlying the regulation of apoptosis, cell growth, and angiogenesis. Somatic mutations in the PIK3CA gene that increase the enzymatic activity of its protein product are associated with a number of cancer types such as breast, colorectal and ovarian cancers. (NCI Thesaurus)

YOU MAY ALSO LIKE

PIK3CA Protein Variant

A variation in the amino acid sequence for the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform protein.

PIK3CA Gene Mutation

A molecular genetic abnormality indicating the presence of a mutation in the PI3KCA (phosphatidyl inositol 3-kinase) gene on chromosome 3q26.32.

PIK3CA Gene Amplification

A molecular genetic abnormality indicating the presence of multiple copies of the PIK3CA (phosphatidyl inositol 3-kinase) gene.

PIK3CA Gene

This gene is involved in apoptosis, cell growth and angiogenesis.

PIK3C2G wt Allele

Human PIK3C2G wild-type allele is located in the vicinity of 12p12 and is approximately 401 kb in length. This allele, which encodes…

PIK3C2G Gene

This gene is involved in the phosphorylation of phosphoinositol.