Pleiotrophin

Definition 1

A secreted growth factor that is mitogenic for endothelial, epithelial, and fibroblast cells but can also induce neurite outgrowth. It functions as a growth factor during neonatal brain development, for primate trophoblast formation, and during tumor invasion, angiogenesis, and metastasis. (NCI Thesaurus)

Definition 2

Heparin-binding neurite outgrowth-promoting factor is a member of a highly conserved human gene family of proteins. It exhibits neurite outgrowth-promoting activity and may play a role in nervous tissue development and/or maintenance. It was renamed pleiotrophin (PTN) to reflect its diverse activities. Expression of this factor is developmentally regulated, increasing in the brain during embryogenesis and reaching its maximum expression at the time of birth. The gene codes for a 168-residue protein that is a precursor for a previously described brain-derived heparin-binding protein of 136 amino acids. (NCI Thesaurus/from OMIM)

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