PNU-214565

A recombinant fusion protein of the bacterial superantigen Staphylococcal enterotoxin A (SEA) and the variable Fab fragment of the C242 monoclonal antibody. Upon administering PNU-214565, the Fab fragment binds to Lewis antigen, a glycoprotein overexpressed in human colon and pancreatic carcinoma cell surfaces, thereby directing PNU-214565 to the tumor target area and providing tumor specificity. Superantigen staphylococcal enterotoxin A (SEA) promotes the crosslinking of T-cell receptor (TCR) Vb regions with major histocompatibility complex (MHC) class II molecules on antigen presenting cells, thereby enhancing cytotoxic T-lymphocyte activation, cytokine production and tumor cell lysis. (NCI Thesaurus)

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