| Health / Medical Topics |
POLB wt Allele
Human POLB wild-type allele is located in the vicinity of 8p11.2 and is approximately 33 kb in length. This allele, which encodes DNA polymerase beta protein, plays a role in DNA base excision repair which entails gap-filling DNA synthesis in a stepwise, distributive fashion. Defects in the POLB gene are associated with certain forms of cancer such as cervical and esophageal cancer. (NCI Thesaurus)
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This gene is involved in DNA repair necessary for DNA maintenance, replication, recombination, and drug resistance.
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