Polymeric Camptothecin Prodrug XMT-1001

A polymeric prodrug of camptothecin (CPT) with potential antineoplastic activity. Polymeric camptothecin prodrug XMT-1001 consists of CPT conjugated to the 60-70 kDa, inert, bio-degradable, hydrophilic copolymer poly[1-hydroxymethylene hydroxymethyl formal] (PHF). Through a dual-phase, non-enzymatic release mechanism, CPT is first released in plasma from XMT-1001 as the lipophilic prodrugs CPT-SI (a succinimidoglycinate derivative) and CPT-SA (a succinamidoyl glycinate derivative), which are then hydrolyzed within tissues to release the lactone form of CPT. CPT inhibits the catalytic activity of DNA topoisomerase I, thereby inhibiting DNA replication and inducing apoptosis. This agent may exhibit a more favorable pharmacokinetic profile than other agents in the same class. (NCI Thesaurus)

YOU MAY ALSO LIKE

Polymerase Gene

Polymerase Genes encode enzymes (Polymerases) that catalyze polymerization reactions, especially of nucleotides to polynucleotides.

Polymerase chain reaction

A laboratory method used to make many copies of a specific DNA sequence. Also called PCR.

Polymerase

Encoded by Polymerase Genes, Polymerase enzymes catalyze polymerization reactions, especially of nucleotides to polynucleotides.

Polymer Chemistry

The study of synthesis and application of polymers. Polymers are any of numerous natural and synthetic compounds of usually high molecular…

Polymer

A chemical compound, typically formed by connecting smaller molecules together, that consists of repeating structures, often arranged in a chain.

Polyhydramnios

An excess quantity of amniotic fluid in the amniotic sac as compared to normal values. Typically associated with an amniotic fluid index…