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Porfiromycin
Pronunciation
Definition 1
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called anticancer antibiotics. (NCI Dictionary)
Definition 2
An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. (NCI Thesaurus)
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Human POR wild-type allele is located in the vicinity of 7q11.2 and is approximately 33 kb in length. This allele, which encodes…
