Post-transplant lymphoproliferative disorder

Pronunciation

Definition 1

A condition in which a group of B-cells grow out of control after an organ transplant in patients with weakened immune systems. This usually happens if the patient has also been infected with Epstein-Barr virus. Post-transplant lymphoproliferative disorder may progress to non-Hodgkin lymphoma. Also called PTLD. (NCI Dictionary)

Definition 2

Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. (NCI Thesaurus/WHO)

YOU MAY ALSO LIKE

Post-Translational Regulation

Post-Translational Regulation is controlled biochemical alteration of proteins involving generally reversible covalent modification or irreversible processing to regulate activity, location, or…

Post-Translational Modification Site

A post-translational modification site refers to amino acid residues within a peptide that act as acceptors for any modifications that do not…

Post-Translational Modification Alteration

Post-Translational Modification Alteration involves a change in the quality of the existing state of biosynthetic enzymatic reactions that occur after polypeptide chain…

Post-Translational Modification

The enzymatic processing of a polypeptide chain after translation from messenger RNA and after peptide bond formation has occurred. Examples include glycosylation,…

Post-Transcriptional Regulation

Any subcellular or molecular event, process, or condition that regulates the processing of a gene transcription product.

Post-Therapy

Occurring after a procedure.