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PRECLINICAL
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I. (adjective)
Sense 1
Meaning:
Of or relating to the early phases of a disease when accurate diagnosis is not possible because symptoms of the disease have not yet appeared
Synonyms:
Classified under:
Relational adjectives (pertainyms)
Pertainym:
medical diagnosis (identification of a disease from its symptoms)
Context examples:
The commercialisation of these life-saving drugs, which is currently decided by a tender system in various states in India, should rather be governed by the outcomes of stringent preclinical evaluations, he suggests.
(‘India needs region-specific snakebite antivenoms’, SciDev.Net)
Improve understanding of the structure and function of molecular targets in order to develop improved assays for such targets; conduct screening, discovery, and preclinical development of novel anti-HIV agents and strategies (such as gene transfer technology and interruption of transmission) directed to the virus and/or host cell; and foster industrial activity and collaborations.
(Discover and Develop HIV Treatments-Preclinical, NCI Thesaurus)
A synthetic polymer (copolymer of 1,3-bis(methylaminocarboxyl)-2-methylenepropanecarbamate and N-vinyl pyrrolidone) of low molecular weight which acts as a nonspecific immune modulator and has been shown to have significant antitumor activity in vitro and in vivo in preclinical and some early clinical studies.
(Copovithane, NCI Thesaurus)
Funding is provided to foster innovative clinical trials of BRMs by peer-reviewed groups of highly experienced clinical and preclinical investigators who have the unique technical capabilities to study new agents in early clinical trials and to address hypothesis-driven issues of mechanisms of action.
(Biological Response Modifiers Program, NCI Thesaurus)
The Gene Therapy and Vector Shared Resource is dedicated to the construction and production of viral and non-viral vectors to Cancer Center faculty members for use in human preclinical and clinical, and animal gene therapy studies, supports protocol development, study strategy development, and gene therapy adverse event risk assessment.
(Gene Therapy and Vector Shared Resource, NCI Thesaurus)
New preclinical research reported in animal models shows that exposure to compounds found in marijuana called cannabinoids (CBs), which includes cannabidiol (CBD) and tetrahydrocannabinol (THC), during early pregnancy can cause malformations in the developing embryo.
(Using both marijuana and alcohol during early pregnancy may increase the likelihood of disrupting fetal development, National Institutes of Health)
The results are based on experiments in which the researchers altered the activity of Cdk5, a gene that preclinical studies have suggested is important for early brain development and may be involved in neurodegenerative diseases, such as ALS, Alzheimer’s and Parkinson’s disease.
(New study implicates hyperactive immune system in aging brain disorders, National Institutes of Health)
RTX has been found to be a highly effective blocker of pain in multiple other preclinical animal models and is in a Phase I clinical trial at the National Institutes of Health Clinical Center for patients with severe pain associated with advanced cancer.
(Chemical from cactus-like plant shows promise in controlling surgical pain, while leaving touch and coordination intact, National Institutes of Health)
The Pharmacology Shared Resource provides Cancer Center investigators conducting preclinical and clinical studies with analytical and technical pharmacology support in the areas of sample handling and tracking, pharmacokinetic modeling, drug-drug interaction, pharmacodynamics, drug assays, in vitro toxicity assays and molecular analysis of tumor tissue; human safety issues, adverse reactions risk evaluation and management, chemotherapy monitoring; assistance in study design, optimal sampling techniques and data interpretation.
(Pharmacology Shared Resource, NCI Thesaurus)
Indeed, both clinical and preclinical studies report that females require almost twice as much morphine as males to produce comparable pain relief, said Hillary Doyle, graduate student in the Murphy Laboratory in the Neuroscience Institute of Georgia State.
(Why Women May Feel More Pain Than Men, The Titi Tudorancea Bulletin)
