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PREDISPOSITION
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I. (noun)
Sense 1
Meaning:
A disposition in advance to react in a particular way
Classified under:
Nouns denoting attributes of people and objects
Hypernyms ("predisposition" is a kind of...):
disposition (a natural or acquired habit or characteristic tendency in a person or thing)
Sense 2
Meaning:
An inclination beforehand to interpret statements in a particular way
Classified under:
Nouns denoting cognitive processes and contents
Hypernyms ("predisposition" is a kind of...):
disposition; inclination; tendency (an attitude of mind especially one that favors one alternative over others)
Hyponyms (each of the following is a kind of "predisposition"):
orientation; predilection; preference (a predisposition in favor of something)
Derivation:
predispose (make susceptible)
Sense 3
Meaning:
Susceptibility to a pathogen
Synonyms:
predisposition; sensitivity
Classified under:
Nouns denoting stable states of affairs
Hypernyms ("predisposition" is a kind of...):
susceptibility; susceptibleness (the state of being susceptible; easily affected)
Attribute:
sensitising; sensitizing (making susceptible or sensitive to either physical or emotional stimuli)
desensitising; desensitizing (making less susceptible or sensitive to either physical or emotional stimuli)
Hyponyms (each of the following is a kind of "predisposition"):
habitus (person's predisposition to be affected by something (as a disease))
sensitisation; sensitization (the state of being sensitive (as to an antigen))
hypersensitivity (pathological sensitivity)
diathesis (constitutional predisposition to a particular disease or abnormality)
Context examples:
One out of fifty hematologically normal individuals exhibit a CSFR1 variant allele (Y969C) that may cause a predisposition to myeloid malignancy.
(Oncogene CSF1R, NCI Thesaurus)
A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma.
(Esophageal Intraepithelial Neoplasia, NCI Thesaurus)
Mutation of the ATM gene causes the disease ataxia telangiectasia which involves an inherited predisposition to some cancers.
(ATM Signaling Pathway, NCI Thesaurus/BIOCARTA)
Predisposition to intestinal cancer requires loss of function of both Msh2/Msh6 and Msh2/Msh3 but Msh3 deficiency alone does not cause cancer predisposition.
(DNA Mismatch Repair Protein MSH3, NCI Thesaurus)
Defects in MMR are associated with genome-wide instability, predisposition to certain types of cancer including HNPCC, resistance to certain chemotherapeutic agents, and abnormalities in meiosis and sterility in mammalian systems.
(Mismatch Repair Pathway, NCI Thesaurus/KEGG)
Methods for diagnosis or monitoring of disease predisposition by translation and validation of molecular discoveries in medicine into the clinical diagnostic setting.
(Molecular Diagnostic Method, NCI Thesaurus)
Research areas of special interest include genetic predisposition, lifestyle factors, environmental contaminants, occupational exposures, medications, radiation and infectious agents, as well as statistics and methods development.
(Division of Cancer Epidemiology and Genetics, NCI Thesaurus)
Cancer Genetics; the science of heredity and the biological process of transmission of characteristics from progenitor to offspring, especially concerning a heritable predisposition to cancer susceptibility.
(Cancer Genetics, NCI Thesaurus)
Breast cancer genetics involve clinical, epidemiologic and/or laboratory evaluations of individuals and their families who are at high risk of developing breast cancer due to hereditary predisposition.
(Breast Cancer Genetics, NCI Thesaurus)
It is characterized by predisposition to cancer, immunodeficiency, high sensitivity to UV and genomic instability of somatic cells. (Oncogene 2001 Dec 13;20(57):8276-80)
(Bloom syndrome, NCI Thesaurus)
