Preimplantation Factor PIF-1

A synthetic version, known as PIF-1, of the peptide Preimplantation Factor (PIF), an embryo-secreted peptide, with potential activity against Graft-versus-Host Disease (GVHD). PIF-1 is believed to have wide-ranging activity on the immunologic system, including a whole host of immunologic changes that resemble pregnancy, in which there is neither graft-versus-host or host-versus-graft disease between the mother and the embryo. Replication of the immunologic profile of pregnancy through the administration of PIF-1 may thus benefit patients undergoing bone marrow transplant (BMT) who experience graft-versus-host disease (GVHD). Native embryonic PIF has been found to have a multi-targeted effect on various aspects of the immune system, coordinated so that there is a successful embryonic implantation and a successful pregnancy. (NCI Thesaurus)

YOU MAY ALSO LIKE

Preimplantation

With regard to an embryo, preimplantation means that the embryo has not yet implanted in the wall of the uterus. Human embryonic…

Pregnenolone

An endogenous steroid hormone synthesized from cholesterol, which can act either as a neuroactive steroid or as a prohormone for progestogens, mineralocorticoids,…

Pregnant Mare Serum Gonadotropin

A polypeptide hormone isolated from the equine placenta. In animals, the activity of pregnant mare serum gonadotropin is similar to that of…

Pregnant During the Study

An indicator as to whether the female subject is pregnant during the study period.

Pregnancy, Puerperium and Perinatal Condition Class

A class of conditions associated with pregnancy, puerperium and perinatal status.

Pregnancy-Related Nausea and/or Vomiting

Nausea and/or vomiting co-occurring with pregnancy.