Procarbazine

Pronunciation

Definition 1

The active ingredient in a drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Procarbazine blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent. (NCI Dictionary)

Definition 2

A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. (NCI Thesaurus)

YOU MAY ALSO LIKE

Procalcitonin Measurement

The determination of the amount of the procalcitonin in a sample.

Procaine Hydrochloride

The hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated…

Procaine

A benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic…

Procainamide Hydrochloride

The hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds…

PROC wt Allele

Human PROC wild-type allele is located within 2q13-q14 and is approximately 11 kb in length. This allele, which encodes vitamin K-dependent protein…

PROC Gene

This gene is involved in the modulation of blood coagulation.