Library / English Dictionary

PROTEASE INHIBITOR

Pronunciation (US):

(GB):

 I. (noun) 

Sense 1

Meaning:

An antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs

Synonyms:

PI; protease inhibitor

Classified under:

Nouns denoting man-made objects

Hypernyms ("protease inhibitor" is a kind of...):

antiviral; antiviral agent; antiviral drug (any drug that destroys viruses)

Hyponyms (each of the following is a kind of "protease inhibitor"):

Crixivan; indinavir (a protease inhibitor (trade name Crixivan) used for treating HIV)

nelfinavir; Viracept (a protease inhibitor (trade name Viracept) used in treating HIV usually in combination with other drugs)

Norvir; ritonavir (a protease inhibitor (trade name Norvir) used in treating HIV)

Invirase; saquinavir (a weak protease inhibitor (trade name Invirase) used in treating HIV)

Holonyms ("protease inhibitor" is a part of...):

drug cocktail; HAART; highly active antiretroviral therapy (a combination of protease inhibitors taken with reverse transcriptase inhibitors; used in treating AIDS and HIV)

Credits

 Context examples: 

Lopinavir/ritonavir is a type of anti-HIV agent and a type of protease inhibitor.

(Lopinavir/ritonavir, NCI Dictionary)

One Kallikrein Inhibitor Unit is identical to the quantity of protease inhibitor (eg, aprotinin) that has the ability to inhibit two kallikrein units by 50% under optimal conditions.

(Kallikrein Inhibitor Unit, NCI Thesaurus)

As an inhibitor of the cytochrome P450 system, delavirdine may result in increased serum levels of co-administered protease inhibitors metabolized by the cytochrome P450 system.

(Delavirdine, NCI Thesaurus)

Encoded by human APP Gene (APP Family), Amyloid Beta A4 Protein Precursor is an N-/O-glycosylated sulfated metal ion-binding type I cell surface protein containing a BPTI protease inhibitor domain.

(Amyloid Beta A4 Protein Precursor, NCI Thesaurus)

This protein has activity as a protease inhibitor.

(Alpha-2-Macroglobulin, NCI Thesaurus)

This allele, which encodes alpha-2-macroglobulin protein, plays a role in various processes as a protease inhibitor.

(A2M wt Allele, NCI Thesaurus)

A member of the serpin family of serine protease inhibitor proteins that inhibits plasminogen activator type proteases.

(Plasminogen Activator Inhibitor, NCI Thesaurus)

An extract of soybeans enriched in Bowman-Birk inhibitor (BBI), a soybean-derived, 71-amino acid, polypeptide and serine protease inhibitor with potential chemopreventive activity.

(Bowman-Birk inhibitor concentrate, NCI Thesaurus)

This gene has activity as a protease inhibitor.

(A2M Gene, NCI Thesaurus)

Plasma serine protease inhibitor (406 aa, ~46 kDa) is encoded by the human SERPINA5 gene.

(Plasma Serine Protease Inhibitor, NCI Thesaurus)