| Health / Medical Topics |
Proteinase 3:PR1 Peptide
A synthetic HLA-A2-restricted nonapeptide derived from proteinase 3 with potential use in cancer immunotherapy. Cytotoxic T lymphocytes (CTL) primed with proteinase 3 PR1 peptide attack leukemic cells that express proteinase 3 aberrantly. Proteinase 3 is a serine proteinase that activates progelatinase A and is involved in metastasis and angiogenesis. (NCI Thesaurus)
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