PTEN Loss

A molecular genetic abnormality indicating the presence of an inactivating mutation in the PTEN gene on chromosome 10q23.

This gene plays a role in signal transduction and apoptosis. It is also involved in the regulation of cell cycle progression. …

A protein that helps control many cell functions, including cell division and cell death. Mutations (changes) in the gene that makes PTEN…

Human PTCH2 wild-type allele is located within 1p33-p34 and is approximately 21 kb in length. This allele, which encodes protein patched homolog…

This gene plays a role in intercellular communication, embryonic structure development, and in tumorigenesis.

Human PTCH1 wild-type allele is located in the vicinity of 9q22.3 and is approximately 65 kb in length. This allele, which encodes…