| Health / Medical Topics |
Pumaprazole
An imidazo-pyridine derivative with reversibly binding acid pump antagonist (APA) activity. Contrary to the mechanism of action of the proton pump inhibitors, which need to be activated by acid within the parietal cell canaliculus and which covalently react through the action of an active intermediate with the SH groups of the H+/K+-ATPase proton pump, pumaprazole competes reversibly with potassium binding on the extracytoplasmic face of the catalytic (alpha) subunit of the proton pump, immediately interrupting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. (NCI Thesaurus)
YOU MAY ALSO LIKE
A device designed to produce a short burst of signal.
Pulsed-field gel electrophoresis (PFGE) is a method used to separate high molecular weight linear DNA fragments that are greater than 50 kilobases…
A serially recurrent arrangement of radiofrequency pulses that are applied to the sample.
The rate of the pulse as observed in an artery, expressed as beats per minute. It can be measured at several anatomical…
Pulse Radiolysis is a technique of exposing a sample of material to a beam of highly accelerated electrons to initiate fast reaction…
The force of a heart contraction measured by the difference between the diastolic and systolic blood pressure measurements.
