Health / Medical Topics

    Pyrimidine Dimer

    Definition 1

    Dimers found in DNA chains damaged by ultraviolet irradiation. They consist of two adjacent pyrimidine nucleotides, usually thymine nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers stop DNA replication. (NLM, Medical Subject Headings)

    Definition 2

    covalently linked adjacent pyrimidine bases (usually thymidine) on a strand of DNA produced by UV light or other radiation; the mutation blocks both transcription and replication until excised and repaired. (NIH CRISP Thesaurus)




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