Regulator of G-Protein Signaling 19

Expressed most in lung, placenta, liver, and heart by human RGS19 Gene (RGS Family), membrane-bound fatty acylated 217-aa 25-kDa Regulator of G-protein Signaling 19 is a guanosine triphosphatase-activating protein, containing 1 RGS domain, that specifically interacts with G protein GAI3 and down-regulates G Alpha i/G Alpha q-linked signaling. Heavily palmitoylated in the Cys string motif and mainly phosphorylated on Ser residues, RGS19 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. RGS19 binds to G-Alpha subfamily 1 members and interacts with GIPC PDZ domain. (NCI Thesaurus)

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