| News / Science News |
Researchers Zero-In on Cholesterol's Role in Cells
For the first time, chemists at the University of Illinois at Chicago have used a path-breaking optical imaging technique to pinpoint cholesterol's location and movement within the cell membrane. They made the surprising finding that, in addition to its many other biological roles, cholesterol is a signaling molecule that transmits messages across the cell membrane.
Cholesterol in a blood vessel. 
Cholesterol is a lipid that gets bad press because of its association with cardiovascular disease. It's been very well studied, but not much is known about its cellular function. What is its role? Is it a bad lipid? Absolutely not -- for example, the brain is about half lipid, and cholesterol is the richest lipid in the brain. A cholesterol deficiency can cause several diseases, and the substance is the starting material for making the body's dozen or so steroid hormones.
Earlier studies showed cholesterol interacts with many regulatory molecules -- mostly cellular proteins -- but it was never thought to be one.
We knew it could play an important role in cell regulation -- for example, in proliferation or development. We know that high-fat diets, which boost cholesterol levels, have been linked to an elevated incidence of cancer. How, is not fully understood.
One of the biggest problems conceptually is that a regulatory or signaling lipid should exist only transiently to transmit the message.
But cholesterol is there all the time. The membrane contains up to 90 percent of a cell's total cholesterol, and cholesterol makes up about 40 percent of the membrane lipids.
Cholesterol lends stability to the membrane, which is actually a double layer of lipid -- or fat -- molecules. The cholesterol gathers into "rafts," which were thought to serve as platforms from which other signaling molecules might operate. But a single cholesterol molecule can itself be the signal trigger.
Cholesterol makes up about 40 percent of the outer layer of the membrane, they found, and only about 3 percent of the inner layer. In response to a specific cell stimulus, the amount in the inner layer more than doubles, and the level in the outer layer drops by the same amount.
The scientists also found that, while in normal cells the concentration of cholesterol in the inner layer is low, in cancer cells it's much higher.
The new study sheds some light on the positive side effect of statin drugs lowering cancer risk. Cho and his coworkers found that treating cells with a statin dramatically lowered the level of cholesterol in the inner layer, leading to suppression of cell growth activity. This suggests a new way to treat cancer through pharmacological modulation of the cellular cholesterol level. (Tasnim News Agency)
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