Revaprazan Hydrochloride

The hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity. Revaprazan concentrates highly in the gastric parietal cell canaliculus and on entering this acidic environment is instantly protonated and binds competitively and reversibly to the potassium binding site of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. (NCI Thesaurus)

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The lead has been left in situ and reused.

Reused Device not Cleaned Evaluation Result

A device that has been used more than once without being cleaned according to the device's cleaning instructions.

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The cardiac lead has been left in situ and reused.

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Device problems related to the use of a device more than once when it is designed for only one use.