Rhodacyanine Analog MKT-077

A synthetic heterocyclic pyridinium compound. MKT-077 is a water soluble lipophilic cationic molecule and an analog of rhodacyanine dye, which partitions into tumor cell mitochondria where it is thought to act as a metabolic poison, leading to G1 arrest and apoptosis. This agent also shows selective cytotoxicity to cancer cells mediated by its binding to the hsp70 family protein mot-2 and reactivation of tumor suppressor p53 function. (NCI Thesaurus)

YOU MAY ALSO LIKE

RHOC wt Allele

Human RHOC wild-type allele is located in the vicinity of 1p13.1 and is approximately 6 kb in length. This allele, which encodes…

RHOC Protein

RHO C protein is a product of the ARHC gene that regulates remodeling of the actin cytoskeleton during cell morphogenesis and…

RHOC Gene

This gene plays a role in signal transduction. It is involved in several cellular functions including cytoskeletal remodeling and cell differentiation. …

RHOB wt Allele

Human RHOB wild-type allele is located in the vicinity of 2p24 and is approximately 53 kb in length. This allele, which encodes…

RHOB Protein

RHO B protein is a GTP-binding protein involved in a signal transduction pathway that controls assembly of focal adhesions and actin stress…

RHOB Gene

This gene plays a role in signal transduction. It is involved in several cellular functions including cell adhesion, differentiation and motility. …