Health / Medical Topics

    Ribonucleotide reductase inhibitor

    Pronunciation

    Definition 1

    A family of anticancer drugs that interfere with the growth of tumor cells by blocking the formation of deoxyribonucleotides (building blocks of DNA). (NCI Dictionary)

    Definition 2

    Any substance that inhibits ribonucleotide reductase, an enzyme that catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleotide diphosphate precursors for de novo DNA synthesis. Inhibition of ribonucleotide reductase can cause inhibition of DNA synthesis and cell growth. (NCI Thesaurus)




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