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RICIN
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A toxic protein extracted from castor beans; used as a chemical reagent; can be used as a bioweapon
Example:
one milligram of ricin can kill an adult
Synonyms:
Classified under:
Hypernyms ("ricin" is a kind of...):
albumen; albumin (a simple water-soluble protein found in many animal tissues and liquids)
toxin (a poisonous substance produced during the metabolism and growth of certain microorganisms and some higher plant and animal species)
Context examples:
The monoclonal antibody component binds to cell surface antigens, thereby targeting delivery of cytotoxic ricin to a specific cell type.
(Murine MCA Ricin Conjugate, NCI Thesaurus)
These antibodies often develop in response to treatment with immunotoxins that are comprised of ricin immunoconjugates and limit the effectiveness of the treatment.
(Human Anti-Ricin Antibody, NCI Thesaurus)
Ricin A chain is toxic to ribosomal activity and protein synthesis, and inhibits cell growth.
(Deglycosylated Ricin A Chain-Conjugated Anti-CD19/Anti-CD22 Immunotoxins, NCI Thesaurus)
The HD37 component binds to CD19, a B-cell restricted antigen, thereby targeting the delivery of the cytotoxic ricin A chain to B-cells.
(Monoclonal Antibody HD37-SMPT-dgA Immunotoxin, NCI Thesaurus)
Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment.
(Di-dgA-RFB4 Immunotoxin, NCI Thesaurus)
An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to a single deglycosylated ricin toxin A-chain (dgA), originated from castor beans.
(IgG-RFB4-SMPT-dgA Immunotoxin, NCI Thesaurus)
The antibody moiety of anti-B4 blocked ricin immunotoxin binds to B lymphocytes that express B4; after internalization of the immunotoxin by the B4-expressing B cell, the ricin moiety cleaves the N-glycosidic bond between the ribose and adenine base at position 4324 in the B lymphocyte 28S ribosomal RNA, resulting in ribosome inactivation, inhibition of protein synthesis, and cell death.
(Anti-B4 Blocked Ricin Immunotoxin, NCI Thesaurus)
An immunotoxin consisting of a murine monoclonal antibody (MCA) conjugated to the toxin ricin.
(Murine MCA Ricin Conjugate, NCI Thesaurus)
This combination agent is able to specifically recognize and bind to CD19 and CD22 expressing tumor cells, thereby targeting the delivery of the cytotoxic ricin A chain to leukemia cells expressing these antigens.
(Deglycosylated Ricin A Chain-Conjugated Anti-CD19/Anti-CD22 Immunotoxins, NCI Thesaurus)
An immunotoxin consisting of the murine anti-CD19 monoclonal antibody HD37 conjugated to a deglycosylated ricin A chain (dgA) via the linking molecule N-succinimidyl-oxycarbonyl-alpha-methyl-alpha-(2-pyridyldithio) toluene (SMPT).
(Monoclonal Antibody HD37-SMPT-dgA Immunotoxin, NCI Thesaurus)
