Ridaforolimus

Pronunciation

Definition 1

A substance being studied in the treatment of soft tissue and bone cancers. It is also being studied in the treatment of other solid tumors and hematologic cancer. Ridaforolimus stops cells from dividing and may cause cancer cells to die. It is a type of mTOR inhibitor. Also called AP23573. (NCI Dictionary)

Definition 2

A small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway. (NCI Thesaurus)

YOU MAY ALSO LIKE

RICTOR wt Allele

Human RICTOR wild-type allele is located in the vicinity of 5p13.1 and is approximately 136 kb in length. This allele, which encodes…

RICTOR Gene

This gene is involved in the regulation of cell growth.

Rickettsiosis

Infections by the genus RICKETTSIA.

Rickettsiaceae

A taxonomic family of Gram negative, non acid fast bacterium in the phylum Proteobacteria that includes the genera Rickettsia and Wolbachia, among…

Rickettsia typhi

A species of aerobic, Gram negative, rod and cocci shaped bacteria assigned to the phylum Proteobacteria. This species is obligately intracellular, motile…

Rickettsia rickettsii

A species of aerobic, Gram negative, rod and cocci shaped bacteria assigned to the phylum Proteobacteria. This species is obligately intracellular, motile…