Risperidone

Pronunciation

Definition 1

A drug used to treat certain mental disorders, such as schizophrenia and bipolar disease. It may also be used to treat certain behavior problems in children. Risperidone blocks the action of certain chemicals in the brain. It is a type of antipsychotic. Also called Risperdal. (NCI Dictionary)

Definition 2

A benzisoxazole derivative with antipsychotic property. Risperidone selectively antagonizes serotonin (5-HT) effects via cortical 5-HT2 receptor, and, to a lesser extent, competes with dopamine at the limbic dopamine D2 receptor. The antagonism leads to decreased psychotic effects, such as hallucinations and delusions. In addition, risperidone has low to moderate affinity for histamine H1, 5-HT1A, 5-HT1C, and 5-HT1D receptors, while it has weak affinity for dopamine D1 and haloperidol-sensitive sigma site receptors. (NCI Thesaurus)

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