RPN1/MECOM Fusion Gene

A fusion gene that results from a chromosomal rearrangement either t(3;3)(q21;q26) or inv(3)(q21q26) which fuses the promoter sequences from the RPN1 gene on either the 5' or 3' side of the coding sequence of the MECOM gene. This rearrangement is associated with overexpression of the MDS1 and EVI1 complex locus protein EVI1 and 3q21q26 syndrome-related leukemias. (NCI Thesaurus)

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RPN1-EVI1 Fusion Protein Expression

The expression of RPN1-EVI1 fusion transcripts in tissues as a result of t(3;3)(q21;q26.2) or inv(3)(q21q26.2) as seen in cases of acute myeloid…

RPN1 wt Allele

Human RPN1 wild-type allele is located in the vicinity of 3q21.3 and is approximately 61 kb in length. This allele, which encodes…

RPN1 Gene

This gene plays a role in post-translational protein modification.

RPL8 wt Allele

Human RPL8 wild-type allele is located in the vicinity of 8q24.3 and is approximately 3 kb in length. This allele, which encodes…

RPL8 Gene

This gene is involved in RNA binding and protein translation.

RPL7A wt Allele

Human RPL7A wild-type allele is located in the vicinity of 9q34 and is approximately 17 kb in length. This allele, which encodes…