RXY/FXpSXP Motif

The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. RXY/FXpSXP Motif is one of two different binding motifs that are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (NCI Thesaurus/from OMIM)

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RXRG wt Allele

Human RXRG wild-type allele is located within 1q22-q23 and is approximately 44 kb in length. This allele, which encodes retinoic acid receptor…

RXRG Gene

This gene plays a role in the mediation of the anti-proliferative effects of retinoic acid.

RXRB wt Allele

Human RXRB wild-type allele is located in the vicinity of 6p21.3 and is approximately 7 kb in length. This allele, which encodes…

RXRB Gene

This gene plays a role in retinoic acid transcriptional regulation and in signal transduction.

RXRA wt Allele

Human RXRA wild-type allele is located in the vicinity of 9q34.3 and is approximately 39 kb in length. This allele, which encodes…

RXRA Gene

This gene plays a role in transcriptional regulation and in the retinoid response pathway.