Health / Medical Topics

    Sabarubicin

    Definition 1

    A disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin. Sabarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also induces apoptosis through a p53-independent mechanism. Sabarubicin is less cardiotoxic than doxorubicin. (NCI Thesaurus)

    Definition 2

    An anticancer drug that belongs to the family of drugs called antitumor antibiotics. (NCI Dictionary)




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