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Semaxanib
Pronunciation
Definition 1
A substance that has been studied in the treatment of cancer. It belongs to the families of drugs called angiogenesis inhibitors and tyrosine kinase inhibitors. Also called SU5416. (NCI Dictionary)
Definition 2
A quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. (NCI Thesaurus)
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Semaphorin-3F (785 aa, ~88 kDa) is encoded by the human SEMA3F gene. This protein is involved in both cell signaling and axon…
Encoded by human SEMA3E Gene (Semaphorin Family), 775-aa 89-kDa (precursor) secreted Semaphorin 3E is a signaling protein containing a Sema domain and…
The meaning of a string in some language; of or relating to the study of meaning and changes of meaning.
Human SEMA4D wild-type allele is located in the vicinity of 9q22.2 and is approximately 137 kb in length. This allele, which encodes…
This gene is involved in both cell-cell signaling and axonal growth cone guidance.
