Health / Medical Topics

    SERPINE1 wt Allele

    Human SERPINE1 wild-type allele is located within 7q21.3-q22 and is approximately 12 kb in length. This allele, which encodes plasminogen activator inhibitor 1 protein, plays a role in preventing the generation of plasmin. Defects in the SERPINE1 gene cause PAI-1 deficiency. Overexpression of this gene is associated with thrombophilia. (NCI Thesaurus)




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