SMAD7 Protein

Encoded by MADH7 Gene (SMAD Family) and induced by TGF-beta and IFNG, ubiquitous (lung, vascular endothelium highest) 426-amino acid SMAD7 Protein is an inhibitory Activin/TGFBR1 signaling component containing DWA/MH1 and DWB/MH2 domains. SMAD7 lacks C-terminal phosphorylation sites of other MAD proteins, suggesting distinct regulation. Adaptor SMAD7 constitutively recruits nuclear E3 ubiquitin ligase SMURF2 to TGFBR complexes preventing SMAD2 access and causing proteasomal and lysosomal receptor degradation. SMAD7-expressing cells are susceptible to apoptosis induced by TGFB, TNFA, serum withdrawal, or loss of cell adhesion. SMAD7 decreases NFKB activity, promoting apoptosis. RAS suppresses SMAD7 inhibition of NFKB and potentiation of apoptosis. MADH7 and MADH6 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI) (NCI Thesaurus)

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SMAD7 Gene

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This gene is involved in signal transduction and regulation of transcription. It also plays a role in development.

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SMAD4 Gene

This gene plays a role in signal transduction and transcriptional activation. It is also involved in suppression of angiogenesis.