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SPINDLE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
Any holding device consisting of a rigid, sharp-pointed object
Example:
the spike pierced the receipts and held them in order
Synonyms:
spike; spindle
Classified under:
Nouns denoting man-made objects
Hypernyms ("spindle" is a kind of...):
holding device (a device for holding something)
Sense 2
Meaning:
A stick or pin used to twist the yarn in spinning
Classified under:
Nouns denoting man-made objects
Hypernyms ("spindle" is a kind of...):
stick (an implement consisting of a length of wood)
Holonyms ("spindle" is a part of...):
spinning frame (spinning machine that draws, twists, and winds yarn)
spinning wheel (a small domestic spinning machine with a single spindle that is driven by hand or foot)
Sense 3
Meaning:
Any of various rotating shafts that serve as axes for larger rotating parts
Synonyms:
arbor; mandrel; mandril; spindle
Classified under:
Nouns denoting man-made objects
Hypernyms ("spindle" is a kind of...):
rotating shaft; shaft (a revolving rod that transmits power or motion)
Holonyms ("spindle" is a part of...):
drive ((computer science) a device that writes data onto or reads data from a storage medium)
Sense 4
Meaning:
A piece of wood that has been turned on a lathe; used as a baluster, chair leg, etc.
Classified under:
Nouns denoting man-made objects
Hypernyms ("spindle" is a kind of...):
piece (a separate part of a whole)
Meronyms (substance of "spindle"):
wood (the hard fibrous lignified substance under the bark of trees)
Sense 5
Meaning:
(biology) tiny fibers that are seen in cell division; the fibers radiate from two poles and meet at the equator in the middle
Example:
chromosomes are distributed by spindles in mitosis and meiosis
Classified under:
Hypernyms ("spindle" is a kind of...):
fiber; fibre (a slender and greatly elongated substance capable of being spun into yarn)
Domain category:
biological science; biology (the science that studies living organisms)
II. (verb)
Sense 1
Present simple (first person singular and plural, second person singular and plural, third person plural) of the verb spindle
Context examples:
A neoplastic process characterized by the proliferation of spindle to cuboidal myoepithelial cells in and around small breast ducts exhibiting cytologic atypia and mitotic activity.
(Atypical Breast Myoepitheliosis, NCI Thesaurus)
This allele, which encodes serine/threonine-protein kinase 6 protein, plays a regulatory role in the G2 and M phases of the cell cycle via involvement in mitotic entry, centrosome duplication and spindle assembly.
(AURKA wt Allele, NCI Thesaurus)
A lipid nanoparticle formulation containing two small interfering RNAs (siRNAs) for kinesin spindle protein (KSP) and vascular endothelial growth factor (VEGF) with potential antitumor activity.
(Anti-KSP/Anti-VEGF siRNAs ALN-VSP02, NCI Thesaurus)
The malignant cells that line the vascular channels are spindle or epithelioid and often display hyperchromatic nuclei.
(Angiosarcoma, NCI Thesaurus)
Like vinblastine, anhydrovinblastine targets and binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and causing tumor cell cycle arrest in the M phase.
(Anhydrovinblastine, NCI Thesaurus)
It is characterized by a neural spindle cell proliferation that replaces the appendiceal mucosa and lymphoid tissue.
(Appendix Neuroma, NCI Thesaurus)
It is characterized by the presence of epithelial nodules embedded in a stroma containing spindle cells.
(Metanephric Adenofibroma, NCI Thesaurus)
Mitotic kinesins play an essential role in regulating the formation of the mitotic spindle as well as regulating their function.
(Mitotic Kinesin Modulator, NCI Thesaurus)
A group of invasive breast carcinomas characterized by the presence of an adenocarcinomatous component which is admixed with a dominant component that is composed of squamous cells, spindle cells, or mesenchymal cells.
(Metaplastic Breast Carcinoma, NCI Thesaurus)
A representative example of the latter is the metaplastic breast carcinoma in which the malignant glandular cells show squamous, spindle cell, or chondroid/osseous differentiation.
(Metaplastic carcinoma, NCI Thesaurus)
