| Library / English Dictionary |
STABILIZING
| Pronunciation (US): |  | (GB): | |
I. (adjective)
Sense 1
Meaning:
Causing to become stable
Example:
the family is one of the great stabilizing elements in society
Synonyms:
stabilising; stabilizing
Classified under:
Similar:
helpful (providing assistance or serving a useful function)
II. (verb)
Sense 1
-ing form of the verb stabilize
Context examples:
The slight excess of alpha units are blocked from precipitation by a molecular chaperone, AHSP, alpha-hemoglobin stabilizing protein.
(Hemoglobin Chaperone Pathway, NCI Thesaurus/BIOCARTA)
The reduction of potentiation prevents cortical seizure foci spreading to adjacent areas, stabilizing the threshold against hyperexcitability.
(Phenytoin, NCI Thesaurus)
In turn, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting in DNA breaks.
(Pegylated Liposomal Irinotecan, NCI Thesaurus)
This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.
(Idronoxil, NCI Thesaurus)
SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.
(Irinotecan/P-glycoprotein Inhibitor HM30181AK Combination Tablet, NCI Thesaurus)
SN-38 binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis.
(liposomal SN-38, NCI Thesaurus)
Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins.
(Nuclear Receptor Gene, NCI Thesaurus)
This results in stabilizing and activating p53-dependent cell cycle arrest and apoptosis.
(Nutlin-3a, NCI Thesaurus)
Polyamines are important for stabilizing DNA structure, for the DNA double strand-break repair pathway, and as antioxidants, and inhibition of ornithine decarboxylase inhibits cell growth.
(Ornithine Decarboxylase Inhibitor, NCI Thesaurus)
This prevents nucleolin from binding to and stabilizing mRNA of the anti-apoptotic Bcl2; destabilizing Bcl2 mRNA leads to a reduction in Bcl2 protein synthesis and induces apoptosis.
(Nucleolin Antagonist IPP-204106N, NCI Thesaurus)
