| Health / Medical Topics |
Stromal Cell-Derived Factor 1
Encoded by human CXCL12 Gene (Intercrine Alpha/Chemokine CXC Family), alternative alpha and beta isoforms of secreted 93-aa 11-kD (precursor) Stromal Cell-Derived Factor 1 are chemoattractant ligands for CXCR4 on T-lymphocytes and monocytes. The beta form contains additional C-terminal sequence. SDF1 is cleaved of an N-terminal tetrapeptide by MMP2 and loses CXCR4 affinity. Human and mouse protein sequences are nearly 92% identical. SDF1 induces intracellular actin polymerization in lymphocytes and may regulate immune surveillance and extravasation of lymphocytes and monocytes rather than in inflammation. With CD4, SDF1 is a coreceptor on CD4+ lymphocytes for HIV-1. (NCI Thesaurus)
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