Health / Medical Topics

    Sumatriptan

    Definition 1

    A sulfonamide triptan with vasoconstrictor activity. Sumatriptan selectively binds to and activates serotonin 5-HT1D receptors in the central nervous system (CNS), thereby constricting cerebral blood vessels. This may lead to a relief in pain from vascular headaches. Sumatriptan may also relieve vascular headaches by decreasing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve. (NCI Thesaurus)

    Definition 2

    A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of migraines. (NLM, Medical Subject Headings)




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