| Health / Medical Topics |
Sumoylation Regulation of Transcriptional Repression Pathway
Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptional repression. (NCI Thesaurus/BIOCARTA)
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