| Health / Medical Topics |
Taltobulin
An analogue of the naturally occurring tripeptide hemiasterlin, with potential antimitotic and antineoplastic activities. Taltobulin binds tubulin in a similar manner as colchicine and inhibits tubulin polymerization. This results in the disruption of the cytoskeleton, ultimately leading to cell cycle arrest in G2/M phase, blockage of cell division and apoptosis. (NCI Thesaurus)
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A morphologic architectural pattern indicating the presence of tall papillary structures.
