Thiazide diuretic

Pronunciation

Definition 1

A type of drug used to treat high blood pressure, edema (extra fluid in the tissues), and other conditions. Thiazide diuretics cause the kidneys to make more urine, which allows the body to get rid of extra fluid and salt. (NCI Dictionary)

Definition 2

Any benzothiadiazide derivative or other thiazide-like agent with diuretic and anti-hypertensive activity. Thiazide diuretics inhibit the sodium-chloride transporter in the distal tubule in the kidneys, thereby suppressing sodium and chloride reabsorption from the distal convoluted tubules (DCT) and increasing the excretion of sodium, chloride, potassium and water. In addition, thiazide diuretics decrease excretion of calcium and uric acid. These agents cause vasodilation possibly by activating calcium-activated potassium channels in vascular smooth muscle and inhibiting various carbonic anhydrases in vascular tissue. (NCI Thesaurus)

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