| Health / Medical Topics |
Thymidylate synthase inhibitor
Pronunciation
Definition 1
A drug that blocks DNA synthesis and may prevent tumor cell growth. It is being studied as a treatment for cancer. (NCI Dictionary)
Definition 2
Any substance that inhibits thymidylate synthase, an enzyme that catalyzes the conversion of uridine monophosphate to thymidine monophosphate, the rate-limiting step in de novo production of dTMP. Inhibition of thymidylate synthase causes inhibition of DNA synthesis and cell proloferation. (NCI Thesaurus)
YOU MAY ALSO LIKE
A protein involved in making and repairing DNA (molecules inside cells that carry genetic information and pass it on from parent to…
A point mutation involving the substitution of Guanosine (a purine base) for Thymidine (a pyrimidine base) in a DNA sequence from eukaryotic…
A point mutation involving the substitution of Cytosine (a pyrimidine base) for Thymidine (a pyrimidine base) in a DNA sequence from eukaryotic…
A point mutation involving the substitution of Adenosine (a purine base) for Thymidine (a pyrimidine base) in a DNA sequence from eukaryotic…
Thymidine phosphorylase (482 aa, ~50 kDa) is encoded by the human TYMP gene. This protein plays a role in pyrimidine metabolism, DNA…
Expressed (as long 266-aa 31-kDa precursor and short 235-aa alternative isoforms) predominantly in liver, pancreas, muscle, and brain by human TK2 Gene…
