TLR7 Agonist 852A

Definition 1

A synthetic imidazoquinoline Toll-like receptor 7 (TLR7) agonist with immunostimulating and potential antitumor activities. TLR7 agonist 852A binds to and activates TLR7, thereby stimulating plasmacytoid dendritic cells (pDC) through the TLR7-MyD88-dependent signaling pathway. Activation of pDC results in secretion of interferon alpha, the production of proimflammatory cytokines, the upregulation of co-stimulatory molecules, and enhanced T and B-cell stimulatory responses. (NCI Thesaurus)

Definition 2

A substance being studied in the treatment of certain adult and childhood blood cancers and other types of cancer. 852A may help the patient's immune system block tumor growth. It is a type of immune system modulator. (NCI Dictionary)

YOU MAY ALSO LIKE

TLR6 wt Allele

Human TLR6 wild-type allele is located within 4p14 and is approximately 3 kb in length. This allele, which encodes toll-like receptor 6…

TLR6 Gene

This gene is involved in immune responses through nuclear factor kappa-B signal transduction.

TLR5 wt Allele

Human TLR5 wild-type allele is located within 1q41-q42 and is approximately 33 kb in length. This allele, which encodes toll-like receptor 5…

TLR5 Gene

This gene plays a role in the mediation of cytokine production and immunity.

TLR4 wt Allele

Human TLR4 wild-type allele is located within 9q32-q33 and is approximately 11 kb in length. This allele, which encodes toll-like receptor 4…

TLR4 Gene

This gene is involved in the mediation of immune responses and in signal transduction events induced by lipopolysaccharide.