Toll-Like Receptor 1

Ubiquitously expressed (highest in spleen, ovary, leukocytes, thymus, and small intestine) by human TLR1 Gene (TLR family), 786-aa 90-kDa (precursor) type I transmembrane Toll-Like Receptor 1 contains a TIR domain and 8 LRR repeats and has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR1 binds to the TLR2 extracellular domain and cooperates with TLR2. TLR1 appears to bind MyD88 via their TIR domains, and to TRAF6, leading to NF-Kappa-B activation, cytokine secretion, and inflammatory response. (NCI Thesaurus)

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