TOP3B wt Allele

Human TOP3B wild-type allele is located in the vicinity of 22q11.22 and is approximately 26 kb in length. This allele, which encodes DNA topoisomerase 3-beta-1 protein, is involved in the ATP-independent breakage of negatively supercoiled single-stranded DNA and subsequent passage/rejoining of the broken DNA. (NCI Thesaurus)

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TOP3B Gene

This gene is involved in DNA recombination, cellular aging and the maintenance of genome integrity.

TOP3A wt Allele

Human TOP3A wild-type allele is located within 17p12-p11.2 and is approximately 41 kb in length. This allele, which encodes DNA topoisomerase 3-alpha…

TOP3A Gene

This gene plays a role in the regulation of DNA topology and recombination in somatic cells.

TOP2B wt Allele

Human TOP2B wild-type allele is located within 3p24 and is approximately 66 kb in length. This allele, which encodes DNA topoisomerase 2-beta…

TOP2B Gene

This gene is involved in chromosome recombination, DNA replication and the regulation of DNA topology during transcription.

TOP2A wt Allele

Human TOP2A wild-type allele is located within 17q21-q22 and is approximately 29 kb in length. This allele, which encodes DNA topoisomerase 2-alpha…