Transporter 1, ATP-Binding Cassette, Sub-Family B

Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP), encoded by the TAP1 gene, is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Loss of TAP1 expression may enhance tumor growth by enabling them to escape T-cell recognition during the effector phase of an antitumor immune response in immunized mice. However, it does not change the immunogenicity of tumor cells in the priming phase. Mutations in the TAP1 gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. (From LocusLink 6890, PMID 12019164 and NCI) (NCI Thesaurus)

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