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TUMOR SUPPRESSOR GENE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
A suppressor gene that blocks unscheduled cell division
Classified under:
Hypernyms ("tumor suppressor gene" is a kind of...):
suppresser; suppresser gene; suppressor; suppressor gene (a gene that suppresses the phenotypic expression of another gene (especially of a mutant gene))
Context examples:
A rare, inherited predisposition to multiple cancers, caused by an alteration in the p53 tumor suppressor gene.
(Li-Fraumeni syndrome, NCI Dictionary)
Inappropriate gain of heterochromatin structure, such as the inactivation of tumor suppressor genes by DNA hyper-methylation at their promoter regions, can be directly linked to carcinogenesis.
(Epigenetic Silencing, NCI Thesaurus)
Further, nanaomycin A may have antineoplastic properties resulting from a reduction in DNA methylation by inhibiting DNA methyltransferase 3B (DNMT3B) and reactivating the tumor suppressor gene RASSF1A.
(Nanafrocin, NCI Thesaurus)
Tumor suppressor genes located in the 18q21-qter region of human chromosome 18.
(DCC wt Allele, NLM, Medical Subject Headings)
This agent may also inhibit RAS oncogene expression and activate tumor suppressor gene p53, resulting in cell differentiation and apoptosis.
(Antineoplaston AS2-1, NCI Thesaurus)
This allele, which encodes membrane-associated transporter protein, plays a role in melanocyte differentiation and is a candidate tumor suppressor gene.
(AIM1 wt Allele, NCI Thesaurus)
A tumor suppressor gene that normally inhibits the growth of tumors.
(P53 gene, NCI Dictionary)
Ad5CMV-p53 induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers.
(Ad5CMV-p53 Gene, NCI Thesaurus)
The PI3K-Akt pathway may be activated through loss or mutation of the inhibitory tumor suppressor gene PTEN.
(Melanoma Pathway, NCI Thesaurus/KEGG)
Molecular mechanisms altered in NSCLC include activation of oncogenes, such as K-RAS and c-erbB-2, and inactivation of tumor suppressor genes, such as p53, p16INK4a, RAR-beta, and RASSF1.
(Non-Small Cell Lung Cancer Pathway, NCI Thesaurus/KEGG)
