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TYROSINE
| Pronunciation (US): |  | (GB): | |
I. (noun)
Sense 1
Meaning:
An amino acid found in most proteins; a precursor of several hormones
Classified under:
Hypernyms ("tyrosine" is a kind of...):
amino acid; aminoalkanoic acid (organic compounds containing an amino group and a carboxylic acid group)
Context examples:
Also called multitargeted receptor tyrosine kinase inhibitor ABT-869.
(ABT-869, NCI Dictionary)
An orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity.
(MET Tyrosine Kinase Inhibitor PF-04217903, NCI Thesaurus)
Schwannomin interacts with the HGF-regulated tyrosine kinase substrate HRS.
(Merlin, NCI Thesaurus)
An orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity.
(ALK Inhibitor X-396, NCI Thesaurus)
Additionally, ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors.
(ALK Inhibitor RO5424802, NCI Thesaurus)
MET tyrosine kinase inhibitor EMD 1214063 selectively binds to MET tyrosine kinase and disrupts MET signal transduction pathways, which may induce apoptosis in tumor cells overexpressing this kinase.
(MET Tyrosine Kinase Inhibitor EMD 1214063, NCI Thesaurus)
This protein is involved in cell proliferation and tyrosine phosphorylation.
(Megakaryocyte-Associated Tyrosine-Protein Kinase, NCI Thesaurus)
An inhibitor of the receptor tyrosine kinase Met (hepatocyte growth factor receptor) with potential antineoplastic activity.
(MET Tyrosine Kinase Inhibitor EMD 1204831, NCI Thesaurus)
An inhibitor of MET tyrosine kinase with potential antineoplastic activity.
(MET Tyrosine Kinase Inhibitor BMS-777607, NCI Thesaurus)
MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.
(MEK Inhibitor MEK162, NCI Thesaurus)
