Vadimezan

Definition 1

A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages. (NCI Thesaurus)

Definition 2

An anticancer drug that is a type of angiogenesis inhibitor. (NCI Dictionary)

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