Vandetanib

Pronunciation

Definition 1

A drug used to treat medullary thyroid cancer that has spread to other parts of the body and cannot be treated by surgery. It is also being studied in the treatment of other types of cancer. Vandetanib prevents the growth of new blood vessels that tumors need to grow. It also blocks enzymes needed for cell growth and may kill cancer cells. It is a type of antiangiogenesis agent and a type of tyrosine kinase inhibitor. Also called Caprelsa and ZD6474. (NCI Dictionary)

Definition 2

An orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis. (NCI Thesaurus)

Definition 3

A substance being studied in the treatment of lung cancer and other types of cancer. It may block the growth and spread of tumor cells and prevent the growth of new blood vessels that tumors need to grow. Vandetanib is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent. (NCI Dictionary)

YOU MAY ALSO LIKE

Vanderbilt-Ingram Cancer Center

The mission of the Vanderbilt-Ingram Cancer Center is to alleviate cancer death and suffering through pioneering research, clinical trials, evidence-based patient-centered care,…

Vancomycin Resistant Enterococcus

A group of bacterial species of the genus Enterococcus that is resistant to the antibiotic vancomycin.

Vancomycin Hydrochloride

The hydrochloride salt of vancomycin, a branched tricyclic glycosylated peptide with bactericidal activity against most organisms and bacteriostatic effect on enterococci. At…

Vancomycin

An antibiotic drug used to fight resistant bacterial infections.

Van der Woude Syndrome

A rare autosomal dominant syndrome caused by mutations in the IRF6 gene. It is characterized by a cleft palate and/or pits on…

van der Waals Attraction

The weak attraction between two or more chemical entities that is caused by the polarization of adjacent atoms or molecules.